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KMID : 0365819680080020081
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Journal of Pusan Medical College
1968 Volume.8 No. 2 p.81 ~ p.100
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An Experimental Study of Acute Pulmonary Edema Following Pulmonary Resection
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Abstract
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This paper is concerned with the mechanism of acute pulmonary edema, which induced by pulmonary resection under various conditions using matured mongrel dogs, experimentally.
Twenty dogs were divided into five groups to investigate the main contributing factors of the pulmonary edema following pulmonary resection observing the water quantity of lung, pulmonary arterial pressure. total protein in the plasma and edema fluid, electrolytes in the serum and pulmonary
tissue, hematocrit and plasma colloidal osmotic pressure, and obtained the following results.
1. Although pulmonary edema was not induced by rapid infusion of large amount of normal saline solution only, but moderate and high degree of pulmonary edema could be induced by unilateral pneumonectomy and massive infusion of normal saline solution coincidently.
2. High degree of pulmonary edema could be induced by increasing of pulmonary capillary permeability with administration of Ethylacetoacetate.
3. In the group of infusion of Indian-ink to block the reticuloendothelial system, high degee of pulmonary edema could be induced by unilateral pneumonectomy and normal saline infusion coincidently.
4. In the group of activating of the reticuloendothelial system by injection of Sodium thiosulfate, pulmonary edema was not induced remarkably even with unilateral pneumonectomy and massive normal saline infusion.
5. In serum, by increasing the degree of pulmonary edema, Sodium and Chloride levels and plasma protein concentrations were decreased, whereas in the pulmonary tissue the Sodium and Chioride levels and protein contents were increased remarkably, this was seemed due to the acute disturbance of electrolytes balance.
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